According to chessgames.com database, the popular moves are:3.d4 with 19,000+ games3.Bb5 with 5,000+ games3.Nc3 with 3,000+ games
Jefferson's choice of 3.Nc3 was played by at least 3 World Champions: Lasker vs Napier in 1904, Kasparov vs Kramnik in 1999, and Topalov vs Kasparov in 2005.
However, Jefferson's 4.Be2 is a rarity. The popular move and the one which was played by Kasparov is 4.d4.Other GMs who played 4.d4 are Vallejo vs Thomassen in Gibraltar 2011, Mamedov vs Nuri in European Ch 2011, Gashimov vs Kotronias in World Team Ch 2010, Savchenko vs IlJushin in Aeroflot 2010.
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